Denosumab for the treatment of osteoporosis a systematic literature review
Introduction: The optimal duration of osteoporosis treatment is controversial. As opposed to bisphosphonates, denosumab does not incorporate into bone matrix and bone turnover is not suppressed after its cessation. Recent reports imply that denosumab discontinuation may lead to an increased risk of multiple vertebral fractures. Methods: The European Calcified Tissue Society ECTS formed a working group to perform a systematic review of existing literature on the effects of stopping denosumab and provide advice on management. Results: Data from phase 2 and 3 clinical trials underscore a rapid decrease of bone mineral density BMD and a steep increase in bone turnover markers BTMs after discontinuation of denosumab.
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Denosumab for the treatment of osteoporosis: a systematic literature review
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