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Optical coherence tomography thesis

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Optical coherence tomography OCT provides depth-resolved three-dimensional images allowing the visualization of subsurface microstructures over large areas in situ and thus is a promising tool for epithelial disease screening. However, it has generally been relegated to a nonspecific diagnostic tool because the optical reflectance back-scattering contrast in OCT images is poorly understood although some contrast agents are available for OCT. This thesis focuses on elucidating the microstructural and ultrastructural bases underlying optical contrast to explore if OCT could provide diagnostic information in epithelial tissues with specificity. We investigate the back-scattered intensity of different intracellular scatterers at the micrometer and nanometer This thesis makes several important contributions to polarisation-sensitive optical coherence tomography PS-OCT through developing no el methods to effectively extract local contrast from birefringence and the orientation of the associated optic axis, at conventional and ultra-high resolution. Optical Coherence Tomography OCT systems are making rapid progress into various areas ranging from medicine and health science up to non-medical areas such as quality control or biometrics.

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Optical coherence tomography thesis
Optical coherence tomography thesis
Optical coherence tomography thesis

Student Theses -Optical Coherence Tomography News

Lin, Nathan Ching. Acquiring the motions of the inner ear sensory tissues provides insight to how the cochlea works. We customized a commercial Spectral Domain Optical Coherence Tomography system for such functions and detailed the software and hardware steps so this powerful system could be more accessible to auditory researchers. The cochlea is surrounded by bones and tissues, and damage to it would make it passive.

Ultra-widefield optical coherence tomography of the human retina

Development of cellular resolution optical coherence tomography. Doctoral thesis, Nanyang Technological University, Singapore. These current standard-of-care tools are associated with many issues such as sampling errors, tissue destruction, and processing artifacts. In addition, it is too traumatic to take a biopsy from tissues like eyes and coronary arteries.
Methods: SDOCT images from 4 glaucoma eyes 4 patients with varying stages of open-angle glaucoma ie, early, moderate, late were qualitatively contrasted with 2 age-matched normal eyes 2 patients. Images were obtained using two experimental SDOCT systems, one utilizing a superluminescent diode and the other a titanium:sapphire laser source, with axial resolutions of about 6 microm and 3 microm, respectively. An SDOCT reference plane microm above the retinal pigment epithelium yielded cup-disc ratios that best correlated with masked physician disc photography cup-disc ratio assessments. The minimum distance band, a novel SDOCT neuroretinal rim parameter, showed good correlation with physician cup-disc ratio assessments, visual field mean deviation, and pattern standard deviation P values range,. RNFL and retinal thickness maps correlated well with disc photography and visual field testing.
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